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So that’s why everyone was looking at you funny at the Thanksgiving table. Using the new Match “skill,” people could ask the device for dating advice, and Alexa would respond with a mix of helpful tips and sassy jokes. Certainly doesn’t sound like something that would immediately backfire in the most predictable, embarrassing way possible!.
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In this study, we identified RME 8 as a novel PI(3)P binding protein implicated in the translocation of Hsc70 to early endosomes for clathrin removal during retrograde transport. Remarkably, the depletion of PI(3)P by MTMR2 S58A attenuated RME 8 endosomal localization. Moreover, we have identified the amino acid determinants required for PI(3)P binding within a region predicted to adopt a pleckstrin homology like fold in the N terminus of RME 8.
As Best Of season comes around each year, we put our heads together in early fall to come up with a theme for what is always our biggest issue of the year. We started out with a loose idea based on royalty and monarchy the various best of winners are the kings and queens of the respective fields. Or something like that.
I too can be brave. I too can love. Only death would have had the power to separate us. The city of Denton, Texas, has acted as a low key hip northern cousin to Austin for a while now, and it’d be a mistake to assume the scene there is homogenously country. Exhibit A: the kinky, spacey pop riffs of Pearl Earl. They’re the B 52s of the DFW metro area, with silver jumpsuits and songs about exorcisms and Ouija board fonts and the post election Bizarro World we currently occupy, as on “Meet Your Maker”: “Why do they keep shooting to kill and rainbow love is seen as mentally ill?/Well I wanna meet your maker/I wanna meet your maker and ask him/How could they even vote for a man who paid a million for his tan?” SS.